PhD student

The University Hospital Ulm with its employees (f/m/d) stands for modern patient care with high quality, top research and medical teaching oriented towards the future as well as training in attractive professional fields. The prerequisites for this are qualified and committed employees (f/m/d). The project with the topic “Defining differences in tumor immunity in lung and ovarian cancer patients depending on the development of a paraneoplastic syndrome (PNS)” is funded by Boehringer Ingelheim University Ulm BioCenter (BIU).

Paraneoplastic neurological syndromes (PNS) are rare neurological diseases that occur in small cell lung and ovarian cancer patients. PNS patients develop a robust immune response against the tumor, which at the same time is also directed against the nervous system due to the expression of onconeuronal antigens in tumor and nerve cells. Less than 1% of cancer patients develop PNS. The research project aims to investigate why PNS and anti-tumor immunity… The University Hospital Ulm with its employees (f/m/d) stands for modern patient care with high quality, top research and medical teaching oriented towards the future as well as training in attractive professional fields. The prerequisites for this are qualified and committed employees (f/m/d). The project with the topic “Defining differences in tumor immunity in lung and ovarian cancer patients depending on the development of a paraneoplastic syndrome (PNS)” is funded by Boehringer Ingelheim University Ulm BioCenter (BIU).

What We Expect From You

Paraneoplastic neurological syndromes (PNS) are rare neurological diseases that occur in small cell lung and ovarian cancer patients. PNS patients develop a robust immune response against the tumor, which at the same time is also directed against the nervous system due to the expression of onconeuronal antigens in tumor and nerve cells. Less than 1% of cancer patients develop PNS. The research project aims to investigate why PNS and anti-tumor immunity develop in some patients while the vast majority of the patients do not show anti-tumor immunity. The role of the immune system, in particular the function of myeloid-derived suppressor cells (MDSCs) in the establishment of an immune-activating or immunosuppressive tumor microenvironment, as well as the influence of different molecular tumor subtypes in the development of PNS will be examined in detail.

• Master’s degree in natural sciences, ideally with a focus on immunology and oncology
• You are willing to work with patient material
• You have in-depth knowledge of immunology, molecular biology and oncology
• Practical experience with cellular immunological assays, cultivation of human primary blood cells and tumor cells, flow cytometry and histology are an advantage, but not a prerequisite
• You are a well-organized team player, who shows initiative, flexibility and great commitment
• You have a class B driving license

What You Can Expect From Us

• Inspiring research field in a highly motivated team
• Excellent training
• Participation in training courses and national and international congresses
• Employment at 65% and payment according to TV-L

Die Einstellung erfolgt durch die Verwaltung des Klinikums im Namen und im Auftrag des Landes Baden-Württemberg. Schwerbehinderte Bewerber/Innen (w/m/d) werden bei gleicher Eignung vorrangig eingestellt. Das Universitätsklinikum Ulm strebt die Erhöhung des Frauenanteils in den Bereichen an, in denen sie unterrepräsentiert sind. Entsprechend qualifizierte Frauen werden um ihre Bewerbung gebeten. Vollzeitstellen sind grundsätzlich teilbar. Eine an die Befristung anschließende Weiterbeschäftigung ist möglich.

Contact

Prof. Dr. Gudrun Strauß

[email protected];

phone:+49-731-500-57033