Sr. Scientist, Mass Spectrometry

The Role:

Scientist with a strong emphasis in bioanalytical mass spectrometry, including processing and analysis of biomolecules such as proteins/peptides, lipids, glycans, mRNA, etc. This role will primarily support our Clinical Development division, as well as colleagues in Platform and other cross-functional groups, by applying cutting-edge LC/MS techniques towards mechanistic and quantitative assessment of Moderna’s mRNA therapies. The candidate must thrive in a fast pace environment with high expectations. Integrity, ability to share experimental issues and troubleshoot, curiosity, collaborative spirit, respect for people, exemplary work ethic and setting the bar high are key values to thrive in our Team.

Here’s What You’ll Do:
Develop, optimize, qualify, and run bioanalytical LC/MS methods for quantitation of various types of biomolecules, particularly proteins (peptides) and lipids
Coordinate with external CROs on method development, qualifications, and validations; review and approval SOWs, protocols, and reports
Support nonclinical in vivo studies to evaluate PK/TK, safety, and efficacy of our drug candidates
Work closely with colleagues in Clinical Development as well as cross-functional groups
Provide mass spectrometry support to scientists in Clinical Development, Platform, and other groups
Assist in writing regulatory submissions and in responding to regulatory queries when needed.
Stay abreast of literature, government guidelines, internal guidance on clinical trial conduct including Good Laboratory Practice (GLP), Good Clinical Practice (GCP), internal SOPs and regulations and White Papers, as appropriate, for pre-clinical and clinical bioanalysis to ensure practices are consistent with regulatory expectations
Limited travel for vendor audits and training

Here’s What You’ll Bring to the Table:
PhD with at least 5 years of post-grad experience, or MS with extensive experience
At least 5 years of demonstrated hands-on experience with mass spectrometry, preferably LC/MS and high-resolution mass spectrometry
(preferred) Experience with peptide mapping, glycan mapping, PTM analysis, protein intact mass analysis, lipid profiling, or related techniques
(preferred) Experience with analytical techniques such as LC, GC, CE, UV, fluorescence, CAD, ELSD, KF, DSC, CD, NGS, Sanger, etc.
(preferred) Ability to develop and implement methods for high throughput or (semi-)automated data analysis
(preferred) Prior experience with method qualification and/or validation
Demonstrated understanding of global regulatory requirements including GLP, GCP and the clinical trial process.
Willingness to learn new concepts and challenge boundaries; adaptability to change
Organization and attention to detail; ability to handle multiple projects in a fast-paced environment
Strong interpersonal skills with an eagerness to work with and support colleagues in other departments

Moderna is pleased to provide you and your family with a comprehensive and innovative suite of benefits, including:
Highly competitive and inclusive medical, dental and vision coverage options
Flexible Spending Accounts for medical expenses and dependent care expenses
Lifestyle Spending Account funds to help you engage in personal enrichment and self-care activities
Family care benefits, including subsidized back-up care options and on-demand tutoring
Free premium access to fitness, nutrition, and mindfulness classes
Exclusive preferred pricing on Peloton fitness equipment
Adoption and family-planning benefits
Dedicated care coordination support for our LGBTQ+ community
Generous paid time off, including:
Vacation, sick time and holidays
Volunteer time to participate within your community
Discretionary winter shut down
Paid sabbatical after 5 years; every 3 years thereafter
Generous Paid Leave offerings, including 18 weeks of 100% paid parental leave for all new parents
401k match and Financial Planning tools
Moderna-paid Life, LTD and STD insurance coverages, as well as voluntary benefit options
Complimentary concierge service including home services research, travel booking, and entertainment requests
Free parking or subsidized commuter passes
Location-specific perks and extras!

Candidates should be aware that Moderna currently maintains a policy requiring all US-based employees to be fully vaccinated against COVID-19 and receive a booster shot once eligible . Newly hired employees must be vaccinated and boosted prior to their employment start date. Moderna is an equal opportunity employer and will provide a reasonable accommodation to those unable to be vaccinated or receive a booster where it is not an undue hardship to the company to do so as provided under federal, state, and local law.

About Moderna

In over 10 years since its inception, Moderna has transformed from a research-stage company advancing programs in the field of messenger RNA (mRNA), to an enterprise with a diverse clinical portfolio of vaccines and therapeutics across seven modalities, a broad intellectual property portfolio in areas including mRNA and lipid nanoparticle formulation, and an integrated manufacturing plant that allows for rapid clinical and commercial production at scale. Moderna maintains alliances with a broad range of domestic and overseas government and commercial collaborators, which has allowed for the pursuit of both groundbreaking science and rapid scaling of manufacturing. Most recently, Moderna’s capabilities have come together to allow the authorized use and approval of one of the earliest and most effective vaccines against the COVID-19 pandemic.

Moderna’s mRNA platform builds on continuous advances in basic and applied mRNA science, delivery technology and manufacturing, and has allowed the development of therapeutics and vaccines for infectious diseases, immuno-oncology, rare diseases, cardiovascular diseases and autoimmune diseases. Moderna has been named a top biopharmaceutical employer by Science for the past seven years. To learn more, visit www.modernatx.com .

Moderna is a smoke-free, alcohol-free and drug-free work environment.

Moderna is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law. Moderna will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.