endTB Clinical Trials Intern M/W

Médecins Sans Frontières

Médecins Sans Frontières, an international medical humanitarian association created in 1971, provides medical assistance to populations whose lives are threatened: mainly in the event of armed conflicts, but also of epidemics, pandemics, natural disasters or exclusion from care. The French section of MSF is present in about thirty countries.

Mission

endTB is a project that aims to provide access to new treatments for patients with multi-drug resistant tuberculosis (MDR-TB). The project is conducted in partnership, within a consortium (involving MSF, Partners in Health (PIH) and Interactive Research and Development (IRD)), a research partnership (involving Harvard Medical School (HMS), Institute of Tropical Medicine-Antwerp (ITM) and Epicentre) and an additional contract with University of California San Francisco (UCSF). The project is co-funded by Unitaid and some consortium partners.

You will be the intern at Sponsor level of the two clinical trials:

– endTB for which the 750 MDR-TB patients are now enrolled and which will end in 2023,

– endTB-Q for which a third of the 324 XDR-TB patients are still to be enrolled and which will end in 2024.

Both clinical trials are conducted under the responsibility of MSF France as Sponsor in 11 sites in 6 countries: India (MSF project), Peru, Kazakhstan, Lesotho (PIH projects), Pakistan (IRD project) and Vietnam (UCSF project).

Reporting to the Trial Manager, you will be part of the central operational team, including about 15 people (Central Study Coordinators, Biostatistician, Data Manager, Clinical Trial Pharmacist, Tuberculosis Laboratory Experts, Pharmacovigilance Manager, Clinical Trial Assistant), distributed among the various partners, some of whom are based in Paris.

You will support the central operational team with the clinical trial data management activities.

You will work closely with the 3 Central Study Coordinators (in charge of the daily follow-up of the country teams), Data Manager and Biostatistician.

Main activities of the intern

Work with Data Manager and Central Study Coordinators to assist with data cleaning activities:

  • Set-up a process and tools to follow-up until resolution of the queries sent by the operational team to the sites (e.g. queries raised for discrepancies between the Case Report Form (CRF) and protocol, queries from reconciliations with laboratory results)
  • Evaluate query frequency and propose resolutions the most common queries
  • Support the reconciliation of missing data and manual data review

Support Central Study Coordinators at local level:

  • Attend regular weekly calls between the sites and the Central Study Coordinators and support in writing and releasing the meeting minutes

This list of activities may be adjusted.

Job requirements

We are looking for an intern interested in research in general, and in clinical trials in particular.

To apply for this internship, you must be at least in the process of completing a Bac+4 or Master 1 in a health or science field. An intern in the process of completing a Bac+5 or Master 2 would also be welcome.

If your education or previous experience has provided you with a good understanding of the international ethical and regulatory requirements of clinical research, this is an asset, but not a prerequisite.

Specificities of the position

Status: 6-month full-time internship, based in Paris. Internship agreement obligatory.

Conditions: Compensation according to the level of studies (from € 4.48 /hour Bac +3 to € 6.55 /hour Bac +5 and above). Restaurant vouchers with a face value of €9 (60% coverage by Médecins Sans Frontières). 50% of the public transport ticket is covered.

Desired start date: July 2022.

How to apply

Please send your application (cover letter and CV in English, mentioning your availability date) until July 3, 2022 included to

https://www.msf.fr/en/get-involved/work-with-us/all-employment-opportunities/endtb-clinical-trials-intern-mw

Only the candidates whose applications have been selected will be contacted.